NT-IITM
Sustainable, Affordable, and Effective for Joint Health

Strong Joints, Gentle Footprint – Health and Sustainability in Harmony

At a time when con­sumers are seek­ing prod­ucts that are both effec­tive for their health and envi­ron­men­tal­ly respon­si­ble, MAGNESIA offers a high­ly com­pelling solu­tion with NT-IITM: an unde­na­tured type II col­la­gen sus­tain­ably sourced from salmon bones.

NT-IITM is the name for the bioac­tive type II col­la­gen offered by MAGNESIA – a spe­cif­ic form derived from the car­ti­lage tis­sue of ver­te­brates that dif­fers sig­nif­i­cant­ly from hydrolyzed or dena­tured types of col­la­gen. The key fac­tor is the preser­va­tion of the nat­ur­al triple-heli­cal struc­ture, which is respon­si­ble for its tar­get­ed effect on joint health. This intact struc­ture makes NT-IITM a par­tic­u­lar­ly com­pelling alter­na­tive, both func­tion­al­ly and eco­log­i­cal­ly, in the field of col­la­gen products.

But what exact­ly is col­la­gen? What types are there? What dis­tin­guish­es hydrolyzed col­la­gen from native col­la­gen, and why is NT-IITM from salmon bones a par­tic­u­lar­ly sus­tain­able and effi­cient choice?

What is collagen, and how do collagen peptides differ?

Col­la­gen is the most abun­dant struc­tur­al pro­tein in the human body, account­ing for approx­i­mate­ly 25–30% of total pro­tein mass. It is essen­tial for the mechan­i­cal strength and elas­tic­i­ty of many tis­sues, as it con­sists of long, sta­ble fiber struc­tures that pro­vide both sta­bil­i­ty and flex­i­bil­i­ty to the body.
In con­trast, col­la­gen pep­tides are small­er frag­ments obtained through the hydrol­y­sis of col­la­gen. These pep­tides are char­ac­ter­ized by their small­er mol­e­c­u­lar size, which allows the body to absorb and process them more easily.

Col­la­gen plays a cen­tral role in many areas of the body: in the mus­cles, it con­tributes to the sta­bil­i­ty and func­tion­al­i­ty of mus­cle fibers, while in the ten­dons, it acts as a vital link between mus­cles and bones. In the skin, col­la­gen pro­vides firm­ness and elas­tic­i­ty; in the lig­a­ments, it ensures joint sta­bil­i­ty and mobil­i­ty. It is also cru­cial in car­ti­lage, where it pro­vides shock-absorb­ing and smooth-mov­ing prop­er­ties, and in the bones, its close inter­ac­tion with cal­ci­um and phos­phate ensures both strength and flex­i­bil­i­ty.

As we age — par­tic­u­lar­ly from the age of 25 onward—the body’s nat­ur­al col­la­gen pro­duc­tion begins to decline, which can lead to vis­i­ble signs of aging and reduced tis­sue func­tion. Col­la­gen pep­tides like NT-IITM, obtained through the enzy­mat­ic break­down of col­la­gen, can stim­u­late col­la­gen metab­o­lism and specif­i­cal­ly pro­mote the regen­er­a­tion of tis­sues. In doing so, they help main­tain and improve the elas­tic­i­ty and strength of the skin, bones, and joints.

Not All Collagen Is the Same: A Comparison of Typesh

Col­la­gen is an incred­i­bly diverse struc­tur­al com­po­nent. A total of 28 dif­fer­ent types of col­la­gen (Types I to XXVIII) are known, along with at least ten addi­tion­al pro­teins that share col­la­gen-like struc­tur­al fea­tures. These types can be grouped into var­i­ous sub­cat­e­gories, each serv­ing spe­cif­ic func­tions with­in the body.
For use in dietary sup­ple­ments and func­tion­al foods, three types of col­la­gen are par­tic­u­lar­ly impor­tant: Type I, Type II, and Type III.

A tar­get­ed intake of these col­la­gen types can help slow down skin aging, pre­vent joint dis­com­fort, and main­tain the struc­tur­al integri­ty of tis­sues – both in cos­met­ic and med­ical contexts.

Kollagen

Typ I Collagen:

This type accounts for the largest share of col­la­gen in the human body and is pri­mar­i­ly found in the skin, ten­dons, bones, and lig­a­ments. It plays a key role in main­tain­ing the sta­bil­i­ty of the skele­tal sys­tem and is cru­cial for the firm­ness and elas­tic­i­ty of the skin.

NT-IITM

Typ II Collagen:

Type II col­la­gen is found pre­dom­i­nant­ly in car­ti­lage tis­sue, where it plays a cen­tral role in shock absorp­tion, elas­tic mobil­i­ty, and the struc­tur­al sta­bil­i­ty of the joints. This makes it espe­cial­ly rel­e­vant for prod­ucts designed to sup­port joint health

Typ III Collagen:

This type is present in the skin and con­nec­tive tis­sue, sup­port­ing the col­la­gen struc­ture of Type I. It plays an impor­tant role in skin regen­er­a­tion, vas­cu­lar struc­ture, and the over­all elas­tic­i­ty of the tissue.

Sources of Collagen and Their Characteristics:

Ori­ginSkin, Bones & Con­nec­tive TissueSkin & BonesCar­ti­lage, Bones & SkinSkin, Scales & Bones of Fish
Col­la­gen TypesI, IIII, IIIIII, II
Char­ac­ter­is­ticsRel­e­vance for Skin and Con­nec­tive TissueSim­i­lar­i­ty to Human Collagen- Low Con­tent of Type I and Type III
– Focus on Type II Col­la­gen (Chick­en Sternum)
– Antiox­i­dant Char­ac­ter­is­tics
– Small­er Mol­e­c­u­lar Size for Eas­i­er Absorption
Ben­e­fits– High Avail­abil­i­ty and Estab­lished Process­es
– Robust Qual­i­ty and Pep­tide Stability
– Good Tol­er­a­bil­i­ty and Bioavail­abil­i­ty
– Tra­di­tion­al Use in the Food and Med­ical Industries
– Easy Digestibil­i­ty and Absorp­tion
– Sup­ports Car­ti­lage Regen­er­a­tion and Joint Health
– More Afford­able than Poul­try Col­la­gen
– Eas­i­ly Digestible with High Bioavail­abil­i­ty
– Pro­motes Car­ti­lage Regen­er­a­tion and Joint Health
– Sus­tain­able Use of By-Prod­ucts from the Fish­ing Industry
Dis­ad­van­tagesPoten­tial Con­sumer Con­cerns Regard­ing Ani­mal Wel­fare and Source– Reli­gious Restric­tions for Cer­tain Groups
– Poten­tial Con­cerns About Ani­mal Wel­fare and Source
– Lim­it­ed Appli­ca­tion Range (Pri­mar­i­ly Type II Col­la­gen)
– Less Cul­tur­al­ly Com­mon in Some Regions
– High­er Cost Due to Com­plex Extrac­tion Processes
High­er Costs Com­pared to Bovine and Porcine Collagen

Caution with “Vegan Collagen”

Plant-based alter­na­tives are increas­ing­ly being mar­ket­ed as “veg­an col­la­gen,” even though they do not con­tain real col­la­gen. These prod­ucts are usu­al­ly based on amino acid blends derived from raw mate­ri­als such as corn, soy, or wheat. These amino acid com­plex­es are intend­ed to the­o­ret­i­cal­ly pro­vide the body with the build­ing blocks need­ed for nat­ur­al col­la­gen pro­duc­tion. How­ev­er, these prod­ucts lack a cru­cial com­po­nent: the bioac­tive pep­tides found only in ani­mal col­la­gen.

Those aim­ing to specif­i­cal­ly improve skin elas­tic­i­ty, pro­mote joint health, or coun­ter­act skin aging should rely on high-qual­i­ty ani­mal col­la­gen, which has sci­en­tif­i­cal­ly proven effects on the skin, bones, and joints — an advan­tage that veg­an alter­na­tives cur­rent­ly can­not offer.

Effect Through Oral Tolerance

The unique effect of NT-IITM is based on the acti­va­tion of reg­u­la­to­ry immune process­es in the gut. Small amounts of native col­la­gen stim­u­late the immune sys­tem to become more tol­er­ant toward col­la­gen-con­tain­ing tis­sues. As a result, NT-IITM can reduce joint inflam­ma­tion, relieve pain, and improve mobil­i­ty — all at a low dosage.

Numer­ous stud­ies con­firm its effec­tive­ness: just 40 mg of NT-IITM per day is suf­fi­cient to achieve a sig­nif­i­cant improve­ment in joint func­tion. This makes NT-IITM a par­tic­u­lar­ly attrac­tive alter­na­tive to high-dose hydrolyzed products.

Comparison: Hydrolyzed vs. Non-Hydrolyzed Collagen

These two modes of action — sup­ply (hydrolysate) ver­sus reg­u­la­tion (NT-IITM) — rep­re­sent the fun­da­men­tal dif­fer­ence between tra­di­tion­al col­la­gen hydrolysates and the tar­get­ed, immuno­log­i­cal­ly active approach of the non-hydrolyzed col­la­gen NT-IITM.

Hydrolyzed Collagen

Hydrolyzed col­la­gen is pro­duced by enzy­mat­i­cal­ly break­ing down long col­la­gen chains into small­er pep­tides. This process makes the prod­uct high­ly sol­u­ble and bioavail­able but also comes with cer­tain challenges:

Indi­vid­ual man­u­fac­tur­ing process: Dif­fer­ent pep­ti­das­es pro­duce vary­ing mix­tures of amino acids and pep­tides, which can be tar­get­ed to act on bone, mus­cle, or skin cells.

Good water sol­u­bil­i­ty: Hydrol­y­sis breaks col­la­gen down into small­er, high­ly water-sol­u­ble peptides.

Effect Depends on Pep­tide Pat­tern: The bio­log­i­cal effect large­ly depends on the pep­tide com­po­si­tion rather than the quantity.

High Dosage Required for Effect: Notice­able ben­e­fits often require high­er dai­ly dos­es (sev­er­al grams).

Pur­pose: Nutri­ent Sup­ply: The pri­ma­ry func­tion is to pro­vide amino acids and pep­tides to sup­port var­i­ous tissues

Non-Hydrolyzed Collagen (NT-IITM)

In con­trast, with non-hydrolyzed col­la­gen, the protein’s nat­ur­al struc­ture is ful­ly pre­served. This leads to a fun­da­men­tal­ly dif­fer­ent mode of action:

Unchanged Struc­ture: NT-IITM remains ful­ly intact in its nat­ur­al triple-heli­cal form, as it is not bro­ken down.

Immunomod­u­la­to­ry Effect: It works through oral tol­er­ance, reg­u­lat­ing inflammation—especially rel­e­vant for joint health.

Effec­tive at Low Dosage: Just 40 mg dai­ly is suf­fi­cient for an effect—significantly less than hydrolyzed collagen.

Bio­log­i­cal Sig­nal­ing: Its action is based on immune inter­ac­tion, not nutri­ent supply.

Tar­get­ed for Inflam­ma­tion: Par­tic­u­lar­ly suit­able for alle­vi­at­ing inflam­ma­to­ry joint conditions.

Why is NT-IITM from salmon bones the better choice?

NT-IITM is pro­duced from salmon bones—a by-prod­uct of fish pro­cess­ing that would oth­er­wise go to waste. This zero-waste uti­liza­tion not only con­tributes to effi­cient resource use but also active­ly helps reduce organ­ic waste in the food industry.

Unlike con­ven­tion­al col­la­gen sources such as beef, pork, or chick­en breast bone, which are often asso­ci­at­ed with inten­sive ani­mal farm­ing and sig­nif­i­cant envi­ron­men­tal impact, NT-IITM offers a marked­ly more envi­ron­men­tal­ly friend­ly alter­na­tive:

Salmon farm­ing requires sig­nif­i­cant­ly less water com­pared to con­ven­tion­al live­stock farming,

uses less land area,

and con­sumes sub­stan­tial­ly low­er amounts of feed.

As a result, fish farm­ing gen­er­ates sig­nif­i­cant­ly low­er CO₂ emis­sions, which pos­i­tive­ly impacts the cli­mate foot­print. Addi­tion­al­ly, the pro­duc­tion of NT-IITM uses raw mate­ri­als that do not com­pete direct­ly with human food sources—especially regard­ing grains, which are com­mon­ly used as ani­mal feed in live­stock farming.

Anoth­er advan­tage: NT-IITM is not only equal­ly effec­tive as oth­er ani­mal col­la­gen sources but also sig­nif­i­cant­ly more cost-effec­tive. This allows your cus­tomers to receive a high-qual­i­ty solu­tion with an excel­lent price-per­for­mance ratio—both sus­tain­able and economical.

The use of by-prod­ucts from fish pro­cess­ing aligns with the prin­ci­ples of the cir­cu­lar econ­o­my and sup­ports a sus­tain­able val­ue cre­ation sys­tem. Thus, NT-IITM stands not only for high func­tion­al qual­i­ty but also for respon­si­ble use of raw materials.

Request more information about NT-IITM now:

Request our sales mate­ri­als for NT-IITM now to receive excit­ing and in-depth infor­ma­tion about our inno­v­a­tive prod­uct for joint health!

Unique Ori­gin & Gen­tle Processing

Sci­en­tif­i­cal­ly Proven Mech­a­nism of Action

Nat­ur­al Com­po­si­tion with High Efficacy

Clin­i­cal­ly Proven Results for Joint Health

Contact us now

Chris­t­ian Nega and the NEM team sup­ports you with tech­ni­cal know-how and finds tai­lor-made solu­tions for your prod­uct idea. 

Also ask for detailed infor­ma­tion about spec­i­fi­ca­tionssafe­ty data sheets or mate­r­i­al sam­ples.

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